{"rewrite":{"id":"r_ce50aa1ebdcbc0b35dd09359","clusterId":"c_cbecf10f78679ec34499407e","slug":"male-fruit-fly-connectome-powers-doomfly-simulation","model":"deepseek-v4-flash","headline":"Male Fruit Fly Connectome Powers DOOMFLY Simulation","summary":"HHMI Janelia Research and Google Research released MaleCNS v1.0, the connectome of a male fruit fly's brain and central nervous system. Coinbase engineer Alex Wormuth is using the dataset to run DOOMFLY, a simulation that converts DOOM screen data into signals for a neural circuit model. Damage to the in-game player sends an artificial aversive stimulus to dopamine cells as a negative reward. After roughly 3000 attempts, no learning effect on survival time has been confirmed.","whyItMatters":"The public release of the male fruit fly connectome has already been put to work in DOOMFLY, a simulation that trains the fly model through dopamine-based negative rewards, though survival time has not improved after roughly 3000 attempts.","webCardHtml":"\u003cp\u003eReleased September 3, MaleCNS v1.0 completes the pair with the female connectome already published by the FlyWire consortium: both sexes of Drosophila melanogaster now have mapped brain and central nervous system wiring, viewable through the open-source Neuroglancer tool.\u003c/p\u003e\u003cp\u003eIn DOOMFLY, DOOM screen data is converted into signals the fly model can receive, triggering neuron activity mapped to controller inputs. Activity in neuron DNp20 is assigned to turning, while DNpe017 drives forward movement and shooting. Taking damage sends an artificial aversive stimulus to dopamine cells as a negative reward, and death restarts the run.\u003c/p\u003e\u003cp\u003eWormuth reports roughly 3000 attempts so far with no confirmed learning effect on survival time. Google Research\u0026#39;s stated next target is a full fish brain map, which would open the door to a fish playing DOOM.\u003c/p\u003e","blueskyPost":"HHMI Janelia and Google Research released MaleCNS v1.0, the male fly connectome. Coinbase engineer Alex Wormuth is running DOOMFLY: DOOM screen data fed into the fly's neural model, damage as a dopamine negative reward. ~3000 attempts, no learning effect on survival confirmed.","twitterPost":"Male fruit fly connectome MaleCNS v1.0 is out. Coinbase engineer Alex Wormuth is running DOOMFLY: DOOM screen data fed into the fly's neural model, damage as a dopamine negative reward. ~3000 attempts so far, no learning effect on survival confirmed.","threadsPost":null,"newsletterBlurb":"HHMI Janelia Research and Google Research released MaleCNS v1.0, the male fruit fly connectome, completing the pair with the female map from the FlyWire consortium. Coinbase engineer Alex Wormuth is using it to run DOOMFLY, a simulation that feeds DOOM screen data into the fly's neural model with damage as a negative dopamine reward. Roughly 3000 attempts in, no learning effect on survival time has been confirmed.","attributionJson":"[{\"source\":\"Automaton\",\"url\":\"https://automaton-media.com/articles/newsjp/20260908-465731/\",\"title\":\"Fly Brain Wiring Map Released, Immediately Used to Play DOOM\"}]","lintFlagsJson":null,"lintHits":0,"costUsd":0,"inputTokens":5112,"outputTokens":5783,"status":"published","repairAttempts":0,"nextRepairAt":null,"factsAttemptedAt":1788843560,"createdAt":"2026-09-08T04:55:09.000Z","publishedAt":"2026-09-08T04:58:21.000Z","updatedAt":"2026-09-08T04:58:21.000Z"},"cluster":{"id":"c_cbecf10f78679ec34499407e","canonicalTitle":"“ハエの脳の配線図“が公開され、すぐさま『DOOM』のプレイに使われる。「被ダメージ」を学習して生き残りを目指す","representativeArticleId":"a_0b08f6c11c6f8793fe44216b","sourceCount":1,"writtenSourceCount":1,"writeAttempts":0,"isSolo":true,"entitiesJson":"{\"anime_titles\":[],\"manga_titles\":[],\"work_titles\":[],\"studios\":[],\"people\":[],\"type\":\"news\",\"domain\":\"other\",\"is_roundup\":false}","contentType":"news","status":"published","firstSeenAt":"2026-09-08T04:16:01.000Z","lastSeenAt":"2026-09-08T04:16:01.000Z","updatedAt":"2026-09-08T04:58:20.000Z"},"attribution":[{"source":"Automaton","url":"https://automaton-media.com/articles/newsjp/20260908-465731/","title":"“ハエの脳の配線図“が公開され、すぐさま『DOOM』のプレイに使われる。「被ダメージ」を学習して生き残りを目指す"}],"entities":{"anime_titles":[],"manga_titles":[],"work_titles":[],"studios":[],"people":[],"type":"news","domain":"other","is_roundup":false},"keyFacts":null}